Showing posts with label magnetoencephalography. Show all posts
Showing posts with label magnetoencephalography. Show all posts

A New Tool for Diagnosing Alzheimer's Magnetoencephalography (MEG)


This development has wonderful implications for diagnosing Alzheimer's; it has far reaching implications for those predisposed by genetics to Alzheimer's disease.

You will be hearing this word quite a bit in the coming months, Magnetoencephalography (MEG). If you read our previous post you will understand why this is likely. Researchers from the University of Minnesota Medical School and Brain Sciences Center at the Minneapolis VA Medical Center recently identified a way to diagnose Alzheimer's and other brain diseases. I am often asked what I am doing for myself now that my mother has been diagnosed with Alzheimer's. The answer to this question is quite long and detailed. I will answers this question when I can on my companion blog, I am an Alzheimer’s CareGiver. For now, I will be investigating the use and potential for Magnetoencephalography as a tool in diagnosing Alzheimer’s disease. As I learn more I will be posting that information on this blog.

For now I can tell you this, the procedure is very expensive and is out of reach financially for the majority of us who are genetically predisposed to Alzheimer’s. Perhaps in the future there will good medical reasons for insurance companies to catch the disease early and treat it. When this occurs the test will become more readily available for those with insurance and likely cheaper for those without that benefit. We can only hope and pay attention to developments

Source Brain Sciences Center, University of Minnesota

Applications

MEG provides scientists a vital neuroimaging tool to gain critical perspectives into the basic mechanisms of the cognitive processes of the healthy, functioning brain in the same lightning speed at which the brain itself operates.

MEG studies also allow researchers valuable insights into the dysfunctional brain with respect to neurological disorders and diseases such as: schizophrenia, stroke, mental retardation, dyslexia and Alzheimer’s disease through measuring these changes in the brain’s electro-magnetic fields.


Magnetoencephalography (MEG) is a rare, complex neuroimaging technique that allows scientists a unique view of the dynamic, interactive brain. There are only a few research centers in the world that have the expertise and capital to incorporate this advanced level of technology into their brain studies.

The uniquely powerful MEG machine at the Brain Science Center uses a non-invasive, whole-head, 248 channel, super-conducting-quantum-interference-device (SQUID) to measure small magnetic signals reflecting changes in the electrical signals in the human brain. The incorporation of liquid helium creates the incredibly-cold conditions (4.2 kelvin) necessary for the MEG’s SQUIDs to be able to measure fields that are literally billions of times weaker than the background magnetic field of the earth.

Investigators at the Center use the MEG to measure these magnetic changes in the active, functioning brain in the speed of milliseconds. Used in conjunction with magnetic resonance imaging (MRI), to relate the MEG sources to brain structures, and functional magnetic resonance imaging (fMRI), for optimal spatial resolution, researchers can now localize brain activity and measure it in the same temporal dimension as the functioning brain itself. This allows investigators to measure, in real-time, the integration and activity of neuronal populations while either working on a task, or at rest. The brains of healthy subjects and those suffering from dysfunction or disease are imaged and analyzed in these MEG studies.

History

This ever-evolving technology began as a single-channel system in the 1970s. Since then, MEG technology has been constantly updated and refined into its current state-of-the-art status. The MEG instrument at the Brain Sciences Center, is one of the few of its caliber in existence. Its 248 SQUID sensors make this imaging machine one of the most powerful and technologically advanced in the world.

What is the Brain Sciences Center?




dysfunctional brain, early signs of alzheimer's, genetically predisposed, I am an Alzheimer’s CareGiver, magnetoencephalography, meg, neuroimaging, predisposed by genetics to Alzheimer's

60 second test could help early diagnosis of Alzheimer's like Dementia



Researchers from the University of Minnesota Medical School and Brain Sciences Center at the Minneapolis VA Medical Center have identified a way to diagnose Alzheimer's and other brain diseases. Using magnetoencephalography (MEG) and various mathematic algorithms, the researchers were able to identify and classify the brain disease in 142 research subjects that had been previously diagnosed. Magnetoencephalography is a non-invasive measurement of magnetic fields in the brain and the tests last between 45-60 seconds.

"This elegantly simple test allows us to glimpse into the brain as it is working," Apostolos P. Georgopoulos said. "We were able to classify, with 100 percent accuracy, the various disease groups represented in the group of research subjects."

This study should be of particular interest to anyone that is genetically predisposed to Alzherimer's and other forms of Dementia.

Currently, brain diseases are diagnosed with behavioral exams, psychiatric interviews, and neuropsychological testing.

Read more about this study being conducted at the University of Minnesota Medical School and Brain Sciences Center on the next page.




Original Source U of M Researchers Discover Noninvasive Diagnostic Tool for Brain Diseases


Additional Source Institute of Physics

Until recently physicians have had to rely on time-consuming and uncertain behavioural examinations to diagnose the onset of brain diseases such as multiple sclerosis, Alzheimer's and schizophrenia.

Research published next week in the Institute of Physics' Journal of Neural Engineering suggests that we could soon be able to diagnose the onset of many brain diseases by analysing the tiny magnetic fields produced by neuron activity in the brain.

This is a significant breakthrough for neurologists and psychiatrists as it could present a fast and simple screening test for brain diseases, while also helping differentiate between different brain diseases that have similar symptoms.

A team of investigators from the University of Minnesota Medical School in Minneapolis, US, led by Professor Apostolos P. Georgopoulos, has been analysing the magnetic charges released when neuronal populations in our brains 'couple'. By comparing the patterns of tiny magnetic charges in healthy brains to those afflicted with common diseases such as Alzheimer's, the team has been able to identify the patterns commonly associated with these debilitating diseases.

A process called magnetoencephalography (MEG), a non-invasive measurement of magnetic fields in the brain, has been used to examine a total of 142 volunteers during tests which last between 45-60 seconds. The team first studied 52 volunteers to find patterns of neural activity that could identify all the different illnesses.

They then tested a further 46 patients to see whether the patterns found from the first group could accurately diagnose disease within a second group. Here, many of the predictors found from the first set of participants also correctly diagnosed more than 90% of subjects in the second sample.

Professor Georgopoulos said, "We want to continue and acquire data from a large number of subjects - patients and matched controls. The throughput of this MEG test is large so we can continue a high rate of testing and we hope that clinical applications can become a reality in a year or two."

Diagnosing illnesses like Alzheimer's has always been very difficult, particularly in the early stages. Physicians are forced to rely on conversations with patients, memory tests, physical examinations and, occasionally, brain scans. It is sometimes not until post-mortem or after a biopsy that cause of illness can be confirmed.