My own personal experience with the combination of Namenda and Dimebon tells me that this combination works. It worked for my mother.
We also have received feedback from the FDA confirming that we can use our Phase 3 CONCERT trial to complete our registration package for mild-to-moderate Alzheimer's disease, provided that the results are robustly positive.
In Alzheimer's speak "more engaged" means "more there." It means more alive, brighter look on the patients face, actually reacting to stimuli like television and the newspaper.
Original content Bob DeMarco, the Alzheimer's Reading Room